老太婆BBBB毛多水厕所

科 室:病理科

性 別:

最高學歷、學位:MD,PhD

職 稱:主任醫師

院內職務:浙大醫學院附屬第一醫院余杭院區副院長,病理科主任

出診信息

注:出診時間如有變化,以當日掛號為準
門診時間 門診地點

個人簡介

教授,博士生導師。浙大醫學院附屬第一醫院余杭院區副院長,病理科主任了,中國健康和疾病人腦組織庫主任。曾任華盛頓大學醫學院神經病理科主任、北京大學基礎醫學院病理系/北醫三院病理科主任。擔任許多世界級神經科學雜志,如American Journal of Pathology,Brain Pathology,Neurological Disease,Neurochemical Res等的編委,并擔任Science,Nature 和PNAS等眾多國際知名科學雜志的審稿人。同時,還常年作為美國NIH 基金評委,也連續多年作為中國國家自然科學基金二審評委。2017年6月,代表中國病理學界成功地獲得了2019年亞太國際病理大會在中國舉辦權。在國際神經病理學術界享有極高聲譽。發表文章約250篇SCI文章,其中包括世界頂級雜志,如Lancet Neurology,Acta Neuropathologica,Science Translational Medicine,Alzheimers & Dementia等,總引用次數超過17,000次,h-指數71,i10-指數199。


專業擅長

神經病理 (神經腫瘤及神經退行性疾?。?。團隊在神經退行性疾病早期診斷生物標志物研究與轉化應用領域處于國際領先地位,尤其是在外周體液分離和鑒定中樞神經系統來源生物標志物領域,更是處于行業引領地位,擁有多項國際/國內專利技術。在阿爾茨海默?。ˋlzheimer’s disease,AD)和帕金森?。≒arkinson’s disease,PD)的早期診斷生物標志物研究方面,章京教授發表的文章在數量和質量上均處于國際同行的第一陣列。


研究方向

神經退行性疾病早期診斷生物標志物研究與轉化應用,從外周體液中分離和鑒定中樞神經系統疾病生物標志物新技術研發等。


成果獎項:(近五年主要成果及獎勵情況)

1. Zhenwei Yu #, Min Shi#, Tessandra Stewart, Pierre-Olivier Fernagu, Yang Huang, Chen Tian, Benjamin Dehay, Anzari Atik, Dishun Yang, Francesca De Giorgi, Franc?ois Ichas, Marie-Hélène Canron, Roberto Ceravolo, Daniela Frosini, Han-Joon Kim, Tao Feng, Wassilios G Meissner*, Jing Zhang*. Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction[J]. Brain, 2020.2.23 Received, will online in 2020.June.SCI

2. Li N#, Wu Y, Zhu L, Huang Y, Liu Z, Shi M, Soltys D, Zhang J*, Chang Q* Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP.[J]. Biochem Biophys Res Commun. 2019 Oct 1;517(4):642-647. SCI

3. Chen Tian#, Genliang Liu, Liyan Gao, David Soltys, Catherine Pan, Tessandra Stewart, Min Shi, Zhiying Xie, Na Liu, Tao Feng *, Jing Zhang *.Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease[J]. Translational Neurodegeneration, 2019, 8(1). SCI

4. Yong‐Xiao Li#, Zhen‐Wei Yu#, Tao Jiang, Li‐Wei Shao, Yan Liu, Na Li, Yu‐Feng Wu, Chen Zheng, Xiao‐Yu Wu, Ming Zhang, Dan‐Feng Zheng, Xue‐Ling Qi, Min Ding, Jing Zhang*, Qing Chang*.SNCA, a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis. Cancer science. 2018,109(4) :1263-1275.SCI

5. Hua Wang#, Tessandra Stewart, Jon B Toledo, Carmen Ginghina, Lu Tang, Anzari Atik, Patrick Aro, Leslie M Shaw, John Q Trojanowski, Douglas R Galasko, Steven Edland, Poul H Jensen, Min Shi, Jing Zhang*.A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer’s Disease and Mild Cognitive Impairment. Journal of Alzheimer's Disease. 2018,61(4):1541-1553.SCI

6. Zhenwei Yu#, Tessandra Stewart, Jan Aasly, Min Shi, Jing Zhang*.Combining clinical and biofluid markers for early Parkinson's disease detection. Annals of clinical and translational neurology. 2018,5(1):109-114.SCI

7. Hua Wang#, Anzari Atik, Tessandra Stewart, Carmen Ginghina, Patrick Aro, Kathleen F Kerr, John Seibyl, Danna Jennings, Poul Henning Jensen, Kenneth Marek, Min Shi, Jing Zhang*.Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study. Neurobiology of disease. 2018,116:53-59.SCI

8. Min Shi#, Lu Tang#, Jon B Toledo, Carmen Ginghina, Hua Wang, Patrick Aro, Poul H Jensen, Daniel Weintraub, Alice S Chen-Plotkin, David J Irwin, Murray Grossman, Leo McCluskey, Lauren B Elman, David A Wolk, Edward B Lee, Leslie M Shaw, John Q Trojanowski, Jing Zhang*.Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia. 2018,14(8):1052-1062.SCI

9. William A Banks#, Andrej Kovac, Petra Majerova, Kristin M Bullock, Min Shi, Jing Zhang*.Tau Proteins Cross the Blood-Brain Barrier. Journal of Alzheimer's Disease. 2017,55(1):411-419.SCI

10. Junichi Matsumoto#, Tessandra Stewart, William A Banks, Jing Zhang*.The transport mechanism of extracellular vesicles at the blood-brain barrier. Current pharmaceutical design. 2017,23(40):6206-6214.SCI

11. Ingrid Chang, Gordana Juric-Sekhar, Desiree Marshall, Jing Zhang*.An incidental finding of choroidal ganglioneuronal hamartoma in a patient with neurofibromatosis type 1. Ophthalmic plastic and reconstructive surgery. 2017,33(3):S40-S42.SCI

12. Min Shi#, Andrej Kovac, Ane Korff, Travis J Cook, Carmen Ginghina, Kristin M Bullock, Li Yang, Tessandra Stewart, Danfeng Zheng, Patrick Aro, Anzari Atik, Kathleen F Kerr, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Thomas J Montine, William Banks, Jing Zhang*.CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2016,12(11):1125-1131.SCI

13. Shijun Wang#, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, Hui Nie, Wei Zhang, Belinda Wilson, Li Yang, Tessandra Stewart, Jau-Shyong Hong, Jing Zhang*.Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons. Journal of neuroinflammation. 2016,13(1):158.SCI

14. Xiangmin Lin#, Min Shi, Jeyaraj Gunasingh Masilamoni, Romel Dator, James Movius, Patrick Aro, Yoland Smith, Jing Zhang*.Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics. 2015,1854(7):779-787.SCI

15. Shijun Wang#, Chun-Hsien Chu, Tessandra Stewart, Carmen Ginghina, Yifei Wang, Hui Nie, Mingri Guo, Belinda Wilson, Jau-Shyong Hong, Jing Zhang*.α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation. Proceedings of the National Academy of Sciences. 2015,112(15):E1926-E1935.SCI

16. Min Shi#, James Movius, Romel Dator, Patrick Aro, Yanchun Zhao, Catherine Pan, Xiangmin Lin, Theo K Bammler, Tessandra Stewart, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Jing Zhang*.Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation. Molecular & Cellular Proteomics. 2015,14(3):544-555.SCI

17. Tianfang Jiang#, Jake Hoekstra, Xin Heng, Wenyan Kang, Jianqing Ding, Jun Liu, Shengdi Chen, Jing Zhang*.P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation. Neurobiology of aging. 2015,36(7):2304-2318.SCI

18. Ge Li#, Kangping Xiong, Ane Korff, Catherine Pan, Joseph F Quinn, Douglas R Galasko, Chunfeng Liu, Thomas J Montine, Elaine R Peskind, Jing Zhang*.Increased CSF E-Selectin in Clinical Alzheimer’s Disease without Altered CSF A β 42 and Tau. Journal of Alzheimer's Disease. 2015,47(4):883-887.SCI

19. Changqin Liu#, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, Jing Zhang*.CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease. Parkinsonism & related disorders. 2015,21(3):271-276.SCI

20. Catherine Pan#, Ané Korff, Douglas Galasko, Carmen Ginghina, Elaine Peskind, Ge Li, Joseph Quinn, Thomas J Montine, Kevin Cain, Min Shi, Jing Zhang*.Diagnostic Values of Cerebrospinal Fluid T-Tau and Aβ 42 using Meso Scale Discovery Assays for Alzheimer's Disease. Journal of Alzheimer's Disease. 2015,45(3):709-719.SCI


社會任職

世界病理學會中國分會秘書長

中國神經科學學會神經退行性疾病分會副主任委員