老太婆BBBB毛多水厕所

科 室:骨科

性 別:

最高學歷、學位:博士

職 稱:教授/主任醫師/博導

院內職務:支部書記/科室副主任

出診信息

注:出診時間如有變化,以當日掛號為準
門診時間 門診地點
星期 一 (上午) 慶春院區
星期 三 (上午) 慶春院區
星期 五 (上午) 慶春院區
星期 二 (上午) 總部一期

個人簡介

王躍,教授,主任醫師,博士生導師,骨科副主任,浙一脊柱外科學術帶頭人。2012年獲加拿大阿爾伯塔大學博士學位,曾在加拿大皇家亞歷山大醫院、香港大學瑪麗醫院、北大三院等世界知名醫院脊柱外科學習交流。主攻脊柱外科,擅長各類退行性脊柱疾患的診治,尤其是脊柱畸形矯正和脊柱微創手術。

以第一作者/通訊作者在國際主流SCI期刊發表論文56篇;主持國家級、省部級和校級各類科研項目20余項;在國際脊柱學術會議作報告20余次,參編《The Intervertebral Disc》等中英文著作6部,申請專利8項??蒲谐晒@國際腰椎學會獎ISSLS獎、中華骨科學會基礎研究獎、省自然科學獎、省醫藥衛生科技獎等多個獎項?,F任AOSpine及國際腰椎學會(ISSLS)會員,以及多個國際脊柱雜志審稿人。


專業擅長

擅長頸椎病和腰腿痛的診治、退行性脊柱疾患的微創治療、以及脊柱側彎與脊柱后凸等脊柱畸形矯正手術。


研究方向

專攻脊柱退行性疾患的流行病學、影像學和椎間盤生物學修復研究。

1. 腰椎間盤突出癥的生物學修復研究;

2. 腰椎間盤突出癥的分子亞型和臨床預后研究;

3. 腰腿痛的神經生物學分子機制研究;

4. 腰椎影像學和臨床流行病學研究 ;


成果獎項:(近五年主要成果及獎勵情況)

一、近五年學術論文

1. Lu X, Chen LH, Jiang C, Cao KL, Gao ZH, Wang Y*. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain, Accepted.

2. Jin J, Liu Y, Jiang C, Shen Y, Chu G, Liu C, Jiang L, Huang G, Qin Y, Zhang Y, Zhang C, Wang Y*. Arbutin-modified microspheres prevent osteoarthritis progression by mobilizing local anti-inflammatory and antioxidant responses. Mater Today Bio. 2022 Jul 19;16:100370. doi: 10.1016/j.mtbio.2022.100370. eCollection 2022 Dec. PMID: 35937573 

3. Cheng L, Feng Z, Jon TG, Chen Z, Wang Y*. Remove the infected interbody cage using endoscopy in lumbar spine revision surgery: A case series and technique report. J Orthop Sci. 2022 Jul 20:S0949-2658(22)00181-6. doi: 10.1016/j.jos.2022.06.014. PMID: 35871062

4. Guan M, Chu G, Jin J, Liu C, Cheng L, Guo Y, Deng Z,  Wang Y*. A Combined Cyanine/Carbomer Gel Enhanced Photodynamic Antimicrobial Activity and Wound Healing. Nanomaterials (Basel). 2022 Jun 24;12(13):2173. doi: 10.3390/nano12132173. PMID: 35808008

5. Zhang C, Cai YZ, Wang Y*. Injection of Leukocyte-Poor Platelet-Rich Plasma for Moderate-to-Large Rotator Cuff Tears Does Not Improve Clinical Outcomes but Reduces Retear Rates and Fatty Infiltration: A Prospective, Single-Blinded Randomized Study. Arthroscopy. 2022 Mar 3:S0749-8063(22)00093-7. doi: 10.1016/j.arthro.2022.02.007. PMID: 35247512

6. Du X, Zhang Q, Wang S, Chen X, Wang Y*. MCAM is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration. J Clin Lab Anal. 2021 Dec 27:e24214. doi: 10.1002/jcla.24214. PMID: 34961985

7. Lu X, Zhu ZW, Pan JJ, Feng ZY, Lv XQ, Battié MC, Wang Y*. Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study. Skeletal Radiol. 2021 Oct 2. doi: 10.1007/s00256-021-03846-0 PMID: 34599674

8. Jiang L, Lin J, Zhao S, Wu J, Jin Y, Yu L, Wu N, Wu Z, Wang Y* Lin M. ADAMTS5 in osteoarthritis: biological functions, regulatory network, and potential targeting therapies. Front Mol Biosci. 2021 Aug 9;8:703110. doi: 10.3389/fmolb.2021.703110. eCollection 2021. PMID: 34434966 

9. Gao Z, Yang Y, Feng Z, Li X, Min C, Zhu Z, Song H, Hu Y, Wang Y*, He X. Chemogenetic stimulation of proprioceptors remodels lumbar interneuron excitability and promotes motor recovery after spinal cord injury. Mol Ther. 2021 Apr 22:S1525-0016(21)00211-2. doi: 10.1016/j.ymthe.2021.04.023. (IF=11.5)

10. Zheng QQ, Shen HT, Tong ZR, Cheng LX, Xu YZ, Feng ZY, Liao SY, Hu XJ, Pang ZY*, Mao ZW*, Wang Y*. A thermosensitive, ROS-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration through inhibiting the secretory autophagy pathway. Theranostics, 2021 Jan 1;11(1):147-163. doi: 10.7150/thno.47723. eCollection 2021. PMID: 33391467 (IF=11.2)

11. Shen HT, Huang JW, Zheng QQ, Zhu ZW, Lv XQ, liu Y*, and Wang Y*. A deep learning based fully automated program to segment and quantify major spinal components on axial lumbar spine MR images. Physical Therapy, 2021 Jun 1;101:1-9. doi: 10.1093/ptj/pzab041. PMID: 33517461

12. Feng ZY, Hu XJ, Zheng QQ, Battié MC, Chen Z, Wang Y*. Cartilaginous endplate avulsion is associated with Modic changes and endplate defects, and residual back and leg pain following lumbar discectomy. Osteoarthritis and Cartilage, 2021 May;29(5):707-717. doi: 10.1016/j.joca.2021.01.010. Epub 2021 Feb 18.

13. Hu XJ, Feng ZY, Huang JW, Zheng QQ, Shen HT, Chen Z, Wang Y*. New MR-based measures for the evaluation of age-related lumbar paraspinal muscle degeneration. European Spine Journal, 2021 Sep;30(9):2577-2585. doi: 10.1007/s00586-021-06811-6. PMID: 33740145

14. Zheng QQ, Hu XJ, Zhang YZ, and Wang Y*. Lumbar disc herniation in a pregnant woman treated with full-endoscopic interlaminar discectomy without X-ray exposure: a case report. Journal of Orthopaedic Science. 2021 Feb 11:S0949-2658(20)30336-5. doi: 10.1016/j.jos.2020.10.021. PMID: 33581926

15. Ding S, Lu X, Liu Z*, Wang Y*. Reduce the fractured central endplate in thoracolumbar fractures using percutaneous pedicle screws and instrumentational maneuvers: Technical strategy and radiological outcomes. Injury. 2021 Apr;52(4):1060-1064.  doi: 10.1016/j.injury.2020.10.014. PMID: 33066988

16. Luo J*, Dolan P, Adams MA, Annesley-Williams DJ, Wang Y*. A predictive model for creep deformation following vertebral compression fractures. Bone. 2020 Aug 16:115595. doi: 10.1016/j.bone.2020.115595. PMID: 32814126

17. Zhang C, Cai YZ*, Lin XJ, Wang Y*. Magnetically Actuated Manipulation and Its Applications for Cartilage Defects: Characteristics and Advanced Therapeutic Strategies. Front Cell Dev Biol. 2020 Jun 30;8:526. doi: 10.3389/fcell.2020.00526. eCollection 2020. PMID: 32695782

18. Maheswaran A, Aiyer SN, Farouk O, El-Sharkawi M, Park JB, O'Brien A, Oluwole I, Wang Y, Arruda AO, Rajasekaran S. Assessment of Interobserver Variability for CT Scan-Based Evaluation of Posterior Ligament Complex Injury in Thoracolumbar Fractures: An International Multicenter Pilot Study. Global Spine J. 2020 Apr;10(2):118-129. PMID: 32206510

19. Lu X, Yang J, Zhu Z, Lv X, Wu J, Huang J, Yu L, Wen Z, Luo J, Wang Y*. Changes of the adjacent discs and vertebrae in patients with osteoporotic vertebral compression fractures treated with or without bone cement augmentation. Spine J. 2020 Jul;20(7):1048-1055. doi: 10.1016/j.spinee.2020.02.012. PMID: 32105771

20. Huang JW, Shen HT, Liu Yong, Wang Y*, Spine Explorer: a deep learning based fully automated program for efficient and reliable quantifications of the vertebrae and discs on sagittal lumbar spine MR images. Spine J. 2020 Apr;20(4):590-599. doi: 10.1016/j.spinee.2019.11.010. PMID: 31759132

21. Chen LH, Battié MC, Yang G, Yuan Y, Chen Z, Wang Y*, Lumbar vertebral endplate defects on magnetic resonance images: prevalence, distribution patterns, and associations with back pain in a population-based sample of Chinese. Spine J. 2020 Mar;20(3):352-360. doi: 10.1016/j.spinee.2019.10.015. PMID:31669615

22. Wu K, Zhao Y, Feng Z, Hu X, Chen Z, Wang Y*. Stepwise local anesthesia for percutaneous endoscopic interlaminar discectomy: technique strategy and clinical outcomes. World Neurosurg. 2020 Feb;134:e346-e352. doi: 10.1016/j.wneu.2019.10.061. PMID: 31634623

23. Wu J, Huang J, Battié MC, Wang Y*. Lifestyle and lifetime occupational exposures may not play a role in the pathogenesis of Modic changes on the lumbar spine MR images. Spine J. 2020 Jan;20(1):94-100. doi: 10.1016/j.spinee.2019.08.009. Epub 2019 Aug 20.

24. Chen Y, Yang H, Wang Y, Zou J. Relationship of endplate changes and low back pain after discectomy. Clin Neurol Neurosurg. 2019 Sep;184:105449. doi: 10.1016/j.clineuro.2019.105449. Epub 2019 Jul 18. PMID: 31344509 

25. Chen Y, Yang H, Zhang L, Wang Y, Zou J. Analyzing the Influence of Modic Changes on Patients with Lower Back Pain Undergoing Conservative Treatment. Pain Res Manag. 2019 Mar 19;2019:8185316. doi: 10.1155/2019/8185316. eCollection 2019.

26. Yang G, Chen L, Gao Z*, Wang Y*. Implication of microglia activation and CSF-1/CSF-1R pathway in lumbar disc degeneration-related back pain. Mol Pain. 2018 Jan-Dec;14:1744806918811238. doi: 10.1177/1744806918811238. PMID: 30326776 

27. Hu XJ, Chen LH, Battié MC, Wang Y*. Methodology and Cohort Profile for the Hangzhou Lumbar Spine Study: A Population-based Study Focusing on Back Health in Chinese. J Zhejiang Univ Sci B. 2018 Jul;19(7):547-558. doi: 10.1631/jzus.B1700484. PMID: 29971993

28. Hu XJ, Chen MJ, Pan J, Liang L, Wang Y*. Is it appropriate to measure lumbar disc degeneration on the middle sagittal MR image? A quantitative image study. Eur Spine J. 2018 May;27(5):1073-1081. doi: 10.1007/s00586-017-5357-3. PMID: 29147797

29. Chen LH, Hu XJ, Battié MC, Wang Y* (2018) Modic Changes in the lumbar spine are common aging related degenerative findings that parallel with disc degeneration, Clinical Spine Surgery, 2018 Aug;31(7):312-317 doi: 10.1097/BSD.0000000000000662 PMID: 29847414

30. Chen L, Chen Z, Wang Y*. Langerhans cell histiocytosis at L5 vertebra treated with en bloc vertebral resection: a case report. World J Surg Oncol. 2018 May 22;16(1):96. doi: 10.1186/s12957-018-1399-1. PMID: 29788958

31. Lv X, Lu X, Wang Y*. Entrapment of a metal foreign body in the cervical spinal canal during surgical procedure: A case report. Medicine (Baltimore). 2018 Apr;97(17):e0548. doi: 10.1097/MD.0000000000010548. PMID: 29703036

32. Hu XJ, Chen Z, Wang Y*. A rare case of concomitant cervical disc herniation and intradural meningioma treated with one-stage posterior surgery. European Spine Journal, 2017 Dec 14. doi: 10.1007/s00586-017-5414-y

33. O'Callaghan P, Szarko M, Wang Y*, Luo J*. Effects of bone damage on creep behaviours of human vertebral trabeculae. Bone. 2017 Nov 3;106:204-210. doi: 10.1016/j.bone.2017.10.022

34. Feng Z, Liu Y, Yang G, Battié MC, Wang Y*. Lumbar Vertebral Endplate Defects on Magnetic Resonance Images: Classification, Distribution Patterns, and Associations with Modic Changes and Disc Degeneration. Spine (Phila Pa 1976). 2018 Jul 1;43(13):919-927. doi: 10.1097/BRS.0000000000002450. PMID: 29019806

35. Pan J, Lu X, Yang G, Han Y, Tong X, Wang Y*. Lumbar disc degeneration was not related to spine and hip bone mineral densities in Chinese: facet joint osteoarthritis may confound the association. Arch Osteoporos. 2017 Dec;12(1):20. doi: 10.1007/s11657-017-0315-6. PMID: 28210985

36. Yang G, Battié MC, Boyd SK, Videman T, Wang Y*. Cranio-caudal asymmetries in trabecular architecture reflect vertebral fracture patterns. Bone. 2017 Feb;95:102-107. doi: 10.1016/j.bone.2016.11.018. PMID: 27876503 (IF=3.71)

37. Feng ZY#, Chen LH#, Hu XJ, Yang G, Wang Y*, Chen Z (2017), Vertebral augmentation can induce early signs of degeneration in the adjacent intervertebral disc: evidence from a rabbit model. Spine. 2018 Oct 15;43(20):E1195-E1203. doi: 10.1097/BRS.0000000000002666. PMID: 29649084

38. Feng ZY, Liu YH, Wei W, Hu S, Wang Y*. Type II Modic Changes may not always represent fat degeneration:A study using MR fat suppression sequence. Spine (Phila Pa 1976). 2016 Aug 15;41(16):E987-94. doi: 10.1097/BRS.0000000000001526. PMID: 26909837 (IF=2.297)

 

二、近五年專利成果

1. 王躍 一種基于橫斷位磁共振圖像的腰椎肌肉測量方法,發明專利,ZL2020114954561

2. 王躍,陸軒。一種腰椎間盤突出癥動物模型的構建方法

3. 王躍,黃嘉煒。一種基于核磁共振圖像的腰椎椎體量化測量方法

4. 王躍,陸軒。一種用于椎間孔入路經皮內鏡腰椎間盤切除術的體表定位裝置

5. 王躍,胡小堅。一種用于獲取脊柱椎體-終板-椎間盤復合體標本的器械組件

6. 王躍,梁亮。腰椎磁共振圖像半自動量化測量軟件(Spine Explorer V1.0),計算機軟件著作權,2018SR946995

7. 王躍,黃彥成,袁穎。脊柱疾病病案在線收集系統軟件(Spine Manager 1.0), 計算機軟件著作權,2018SR144404

8. 王躍,一種頸椎前路手術用充氣式頸椎體位調節裝置,新型實用專利,ZL201520866994.5

 

三、獲得榮譽

1. 2018年8月,浙江省科學技術廳, 自然科學三等獎 (椎體和終板在腰椎間盤退變和腰痛中的病理作用及機制研究),排名第一;

2. 2018年4月,浙江省醫藥衛生科技獎二等獎(腰椎椎體和終板在腰椎退行性疾病中的病理作用和臨床流行病學研究),排名第一;

3. 2017年11月,中國醫藥教育協會科技創新二等獎(腰椎間盤退行性疾病發病機制新發現及其治療過程中的意義),排名第二;

4. 2016年10月,中華骨科學會(COA)骨科基礎青年研究二等獎,排名第一;

5. 2016年度,浙江大學醫學院“優秀班主任”;

6. 2016 AOSpine Fellowship

7. 2014年9月,香港大學李嘉誠醫學院鄭裕彤博士(Dr. Cheng Yu Tung)獎學金;

8. 2014 AOSpine Fellowship

9. 2012年5月,國際腰椎學會(ISSLS),ISSLSPrize(脊柱研究最高國際學術榮譽),15,000 USD, 排名第一;


社會任職

  • 國際腰椎協會(ISSLS)會員

  • AOSpine會員

  • 國際微創脊柱外科學會年會(ISMISS)青年委員

  • 中國醫師協會浙江省分會神經修復協會副主任委員

  • 中國研究型醫院學會頸椎疾病健康管理與加速康復專業委員會委員

  • 浙江省抗癌協會第七屆骨與軟組織腫瘤專業委員會副主任委員

  • 浙江省康復醫學委員會脊柱脊髓損傷委員會委員

  • 浙江省醫學會骨科分會青年委員、骨病組副組長

  • 浙江省中西結合骨傷醫學會委員

  • 中國醫促會結合骨傷醫學會青年委員

  • 中國醫促會脊柱內鏡分會委員

  • 中華醫學會結核病學分會骨結核專業委員會委員

  • Spine、European Spine Journal 審稿人